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KMID : 0359320030430040573
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Korean Journal of Veterinary Research
2003 Volume.43 No. 4 p.573 ~ p.578
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Mechanism of vasodilatation induced by substance P in isolated rabbit renal artery
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Kim, Joo-heon/김주헌
Jeon, Seok-cheol/Hong, Yonggeun/전석철/홍용근
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Abstract
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The effects of removing the endothelium on the vasodilatory response to substance P, calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) was examined in the isolated rabbit renal artery. The vasodilator response to substance P (0.1 μM) was completely absent in vessels in which the endothelium had previously been removed. There was no significant difference in the vasodilatation produced in response to CGRP (0.1μM), or VIP (0.1 μM) in the intact and removed-endothelium rabbit renal artery segments. L-NAME (100 μM) significantly reduced the vasodilatory response to substance P (0.1 μM). This inhibition was significantly attenuated when L-arginine (10 mM) was also present in the organ bath along with L-NAME (100 μM). Indomethacin (1 μM) did not significantly affect the vasodilatation produced in response to substance P (0.1 μM). The inhibitory effect of L-NAME (100 μM) and indomethacin (1 μM) on the vasodilatory response to substance P (0.1 μM) was not significantly different from that produced by L-NAME (100 μM) alone. This study indicates that substance P induced vasodilatation via an endothelium-dependent mechanism in the isolated rabbit renal artery. It also established that CGRP and VIP induced vasodilatation by an endothelium-independent mechanism and substance P-induced vasodilatation is at least partially via NO.
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